Search on: IMMUNO-STIMULATING COMPLEXES 
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Descriptor English:   ISCOMs 
Descriptor Spanish:   ISCOMs 
Descriptor Portuguese:   ISCOMs 
Synonyms English:   ISCOM
Immuno-Stimulating Complexes
Complexes, Immuno-Stimulating
Complexes, Immunostimulating
Immuno Stimulating Complexes
Immunostimulating Complexes  
Tree Number:   D20.215.894.860.449
Definition English:   A formulation for presenting an antigen to induce specific immunologic responses. It consists of an assembly of antigens in multimeric form. The assembly is attached to a matrix with a built-in adjuvant, saponin. ISCOMs induce strong serum antibody responses, and are used as highly immunogenic forms of subunit vaccines. 
Indexing Annotation English:   coord IM with specific type of vaccine (IM or NIM); DF: ISCOM
Pharmacological Action:   Adjuvants, Immunologic
 
See Related English:   Saponins
 
History Note English:   92 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AN analysis BI biosynthesis
BL blood CF cerebrospinal fluid
CH chemistry CL classification
CT contraindications DE drug effects
EC economics GE genetics
HI history IM immunology
IP isolation & purification ME metabolism
PD pharmacology PO poisoning
RE radiation effects TU therapeutic use
TO toxicity UL ultrastructure
UR urine  
Record Number:   30027 
Unique Identifier:   D016882 

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